Human, animal and environmental health are deeply interconnected, yet these relationships have rarely been quantified globally. Integrating records of more than 14,000 human outbreaks and three million domestic animal disease events across 153 countries, I examine associations among human outbreaks, animal disease and environmental change. Environmental factors, including tree-cover loss, urban expansion and temperature anomalies, were stronger predictors of human outbreaks than animal disease burden, with these associations varying across socioeconomic and healthcare contexts.
